[目的]探讨甲状腺透明变梁状肿瘤(HTT)的临床病理特征、诊断和鉴别诊断。[方法]收集4例HTT临床及病理资料,采用EnVision免疫组化和特殊染色,结合相关文献进行分析。[结果]4例HTT患者均为女性,体检和其他病变复查B超检查时偶然发现,均行手术治疗。肿瘤呈孤立性结节,包膜完整,瘤细胞呈梁状和腺泡状生长,可见核沟及核内包涵体,间质中见透明玻璃样变物质。Ki-67(MIB-1)瘤细胞胞膜弥漫阳性,间质透明变物质PAS阳性。[结论 ]HTT是一种罕见的甲状腺肿瘤,具有特征性的组织学结构和免疫表型,需病理检查确诊,大多预后良好。 [Objective] To investigate the clinicopathological features, diagnosis and differential diagnosis of thyroid transparent metastatic tumors (HTT). [Methods] The clinical and pathological data of 4 cases of HTT were collected and analyzed by EnVision immunohistochemistry and special staining combined with related literatures. [Results] The 4 cases of patients with HTT were all female, and physical examination and other pathological findings were occasionally found by B-mode ultrasound examination. All patients underwent surgical treatment. Tumors were isolated nodules, complete capsule, tumor cells were beam-like and acinar growth, showing the ditch and nuclear inclusions, interstitial see transparent glass-like substances. Ki-67 (MIB-1) tumor cell membrane diffuse positive, interstitial transparent substance PAS positive. [Conclusion] Hyperthyroidism is a rare thyroid tumor characterized by histological structure and immunophenotyping. Hyperthyroidism is diagnosed by pathology and most of the prognosis is good.