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目的探讨乳腺癌患者治疗前后血清糖类抗原CA153(CA153)、唾液酸(SA)和肿瘤坏死因子-α(TNF-α)含量。方法应用放射免疫分析和分光光度计法对32例乳腺癌患者进行了治疗前后血清CA153、SA、TNF-α含量检测。并以30名正常女性作比较。结果治疗前乳腺癌患者血清CA153、SA、TNF-α水平均非常显著地高于正常人组(P<0.01),治疗后6个月则与正常人比较无显著性差异(P>0.05)。结论乳腺癌患者血清CA153、SA、TNF-α含量的变化与该病的发生和发展密切相关。
Objective To investigate the levels of serum carbohydrate antigen CA153, sialic acid (SA) and tumor necrosis factor-α (TNF-α) in patients with breast cancer before and after treatment. Methods The levels of serum CA153, SA and TNF-α in 32 patients with breast cancer before and after treatment were measured by radioimmunoassay and spectrophotometer. And 30 normal women for comparison. Results The levels of serum CA153, SA and TNF-α in patients with breast cancer before treatment were significantly higher than those in normal controls (P <0.01). There was no significant difference between the two groups at 6 months after treatment (P> 0.05). Conclusion The changes of serum CA153, SA and TNF-α in patients with breast cancer are closely related to the occurrence and development of the disease.