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在豚鼠作内淋巴管和囊堵塞手术后,作者观察了利尿剂对这种膜迷路积水的作用。77只豚鼠分为三组:组1于闭塞术后第1天服醋唑磺胺(159～434mg/kg),每日1次,服1月;组2于术后第1天服氯噻酮(72～182mg/kg),每两天服1次,服一个月;组3不服任何药物做对照。各实验组分别观察7天、8天、9天、1个月和4个月。内耳用火棉胶包埋连续切片,耳蜗中阶容积用计算机求积仪从连续切片中求出,测定正常中阶和积水中阶的面积。在日服159～434mg/kg醋唑磺胺30天的动物中,膜迷路积水达不到未服药动物程度,但在服药一个月后停药3个月的动物则与不服药组无差
After guinea pigs underwent endolymphatic and balloon occlusion surgery, the authors observed the effect of diuretics on this membranous labyrinth. 77 guinea pigs were divided into three groups: Group 1 was given acetosyzamid (159 ~ 434mg / kg) on the first day after the occlusion, once a day for 1 month; group 2 took chlorthalidone (72 ~ 182mg / kg), taken once every two days for one month; group 3 did not accept any drug as a control. Each experimental group were observed 7 days, 8 days, 9 days, 1 month and 4 months. The inner ear was embedded in a series of pieces with fire cotton glue. The middle volume of the cochlea was calculated from the serial sections by computer and plotted to determine the area of middle and mid-stage of normal. In the daily doses of 159 ~ 434mg / kg of azastrobin for 15 days, the labyrinthine lost water did not reach the level of non-administered animals, but the animals stopped for 3 months one month after taking the drug had no difference