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恶性肿瘤的转移是造成肿瘤患者死亡的最主要的原因。尽管通过手术、化疗、放疗等综合治疗措施,肿瘤患者的五年生存率有了很大的提高,但对于转移瘤的治疗仍没有根本性的突破。因此研究肿瘤转移的分子机制成为肿瘤研究领域的热点。Kiss-1是Lee等1996年在黑色素瘤细胞株发现的一个新的肿瘤转移抑制基因。Kiss-1基因在多种恶性肿瘤中表现出抑制肿瘤转移的能力。Kiss-1基因与恶性黑色素瘤、乳腺癌、甲状腺癌、
Malignant tumor metastasis is the leading cause of death of cancer patients. Although the five-year survival rate of cancer patients has been greatly improved through comprehensive treatment measures such as surgery, chemotherapy and radiotherapy, there is still no fundamental breakthrough in the treatment of metastases. Therefore, the study of molecular mechanisms of tumor metastasis has become a hot topic in the field of cancer research. Kiss-1 is a new tumor metastasis suppressor gene discovered by Lee et al. In 1996 in melanoma cell lines. The Kiss-1 gene has been shown to inhibit tumor metastasis in a variety of malignancies. Kiss-1 gene and malignant melanoma, breast cancer, thyroid cancer,