论文部分内容阅读
目的：探索内皮素－１（ＥＴ－１）及前列环素（ＰＧＩ２）在内毒素血症所致肝损害中的作用。方法：选用Ｗｉｓｔａｒ大鼠１２０只，分为对照组、内毒素组、内毒素＋ＥＴ－１抗体组、内毒素＋前列环素组。观察了伤后３、６、９、１２和２４ｈ血浆中ＥＴ－１、谷丙转氨酶（ＧＰＴ）的含量；肝组织中ＥＴ－１、ＰＧＩ２、乳酸脱氢酶（ＬＤＨ）和丙二醛（ＭＤＡ）的含量。结果：内毒素血症时，血浆和肝组织中ＥＴ－１明显升高。血浆ＧＰＴ、肝组织中ＬＤＨ、ＭＤＡ均显著升高。肝组织ＥＴ－１与ＭＤＡ呈显著正相关。内皮素抗体部分拮抗内毒素所致肝损伤。结论：内毒素血症时ＥＴ－１对肝组织有一定损害作用。ＰＧＩ２通过舒张血管平滑肌对肝组织有一定保护作用。
Objective: To explore the role of endothelin-1 (ET-1) and prostacyclin (PGI2) in liver injury induced by endotoxemia. Methods: 120 Wistar rats were selected and divided into control group, endotoxin group, endotoxin + ET-1 antibody group and endotoxin + prostacyclin group. The levels of ET-1 and GPT in plasma were detected at 3, 6, 9, 12 and 24 hours after injury. ET-1, PGI2, LDH and MDA ) Content. Results: In endotoxemia, ET-1 was significantly increased in plasma and liver tissue. Plasma GPT, liver tissue LDH, MDA were significantly increased. Liver tissue ET-1 and MDA showed a significant positive correlation. Endothelin partially antagonizes endotoxin-induced liver injury. Conclusion: Endotoxemia ET-1 has a certain damage on liver tissue. PGI2 has a protective effect on liver tissue through relaxing vascular smooth muscle.