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目的:探讨化疗前后n 18F-脱氧葡萄糖(FDG)PET/CT显像左心室标准摄取值(SUVn LV)能否用于诊断非霍奇金淋巴瘤(NHL)化疗后心肌损伤。n 方法:回顾性分析2016年1月至2019年6月22例确诊为NHL并接受含蒽环类药物化疗方案治疗的患者[男13例，女9例，年龄(58±13)岁]资料。患者化疗前后均于常州市第一人民医院行门控心肌灌注显像(GMPI)及全身n 18F-FDG PET/CT显像。利用化疗前后GMPI舒张功能减退情况判断是否存在化疗后心肌损伤，使用两独立样本n t检验及配对n t检验分析比较心肌损伤与未损伤患者化疗前后SUVn LV的变化情况，使用受试者工作特征(ROC)曲线分析SUVn LV能否用于诊断化疗后心肌损伤。n 结果:相比于心肌未损伤患者(16例)，心肌损伤患者(6例)化疗后左心室射血分数(LVEF)降低程度较大[ΔLVEF：(-5.8±7.5)%与(2.7±3.8)%；n t＝2.657，n P0.05)。相比于心肌未损伤患者，心肌损伤患者具有更高的ΔSUVn LV(n t值：2.494、2.163，均n P0.05). Compared with patients without myocardial injury, patients with myocardial injury had higher ΔSUVn LV (n t values: 2.494, 2.163, both n P<0.05) and lower pre-chemotherapy SUVn LVmax (n t=2.436, n P<0.05). ROC curve analysis showed that ΔSUVn LVmax and ΔSUV n LVmean could be used for the detection of chemotherapy induced cardiotoxicity, and higher area under curve (AUC) of ΔSUV n LVmaxwas found (AUC=0.844, 95% n CI: 0.673-1.000). When the threshold value was 1.1, the sensitivity and specificity of ΔSUV n LVmax in the detection of myocardial injury were 5/6 and 13/16, respectively.n Conclusions:Higher ΔSUV n LVmax and ΔSUV n LVmean, as well as lower baseline SUVn LVmax are correlated with cardiotoxicity of anthracycline. ΔSUV n LVmax has a potential for the diagnosis of anthracycline induced cardiotoxicity in patients with NHL.n