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目的 探讨非胰岛素依赖型糖尿病 (NIDDM )及其血管并发症的危险因素。方法 对安徽医科大学第一附属医院的住院及门诊患者进行问卷调查。在对所得资料进行描述性分析的基础上采取单因素、多因素LOGISTIC和COX比例风险模型进行深入分析。结果 ①年龄、既往HBP病史、DM家族史、肥胖、饭量过大、收入水平等因素为NIDDM的危险因素 ,OR值分别为 1 0 4、3 73、14 2 8、2 15、5 6 5、1 6 9,P <0 0 1,在妇女生殖生育各因素中 ,巨大儿生产史是一危险因素 ,OR =3 82 ,P <0 0 5。职业性体力劳动为保护性因素 ,OR =0 4 5,P <0 0 1。②新发NIDDM患者罹患微小血管并发症的危险因素为吸烟、HBP病程和油腻食品 ,OR值分别为 6 135、1 0 94、4 991,P <0 0 1。教育程度为保护性因素OR =0 39,P <0 0 1。③NIDDM患者罹患大血管并发症的危险因素为HBP病程、吸烟、和HBP家族史 ,RR值分别为 1 384、2 6 18和1 995,P <0 0 5。降压治疗、饮食控制为保护性因素 ,RR值分别为 0 533和 0 70 2 ,P <0 0 1。④NIDDM患者罹患HBP的危险因素为HBP家族史 ,RR =1 347,P <0 0 5。良好的血糖控制为保护性因素RR =0 4 57,P <0 0 1。结论 在NIDDM的防治和宣教中 ,应当着重针对高龄、肥胖、有家族史和有既往HBP病史的人群 ,提
Objective To investigate the risk factors of non-insulin-dependent diabetes mellitus (NIDDM) and its vascular complications. Methods The first affiliated hospital of Anhui Medical University inpatients and outpatients were surveyed. On the basis of the descriptive analysis of the data obtained, the single-factor, multi-factor LOGISTIC and COX proportional hazards models were used to conduct in-depth analysis. Results ① Age, past history of HBP, family history of DM, obesity, excessive appetite and income were the risk factors of NIDDM with OR values of 104, 73, 73, 82, 1 6 9, P <0 01. Among the various factors of women’s reproductive growth, the production history of macrosomia was a risk factor, OR = 3 82, P <0 05. Occupational manual labor as a protective factor, OR = 0 4 5, P <0 0 1. ② The risk factors for microvascular complications in newly diagnosed NIDDM patients were smoking, HBP duration and greasy food, the OR values were 6 135,1 0 94,4 991, P 0 01, respectively. The educational level was protective factor OR = 0 39, P <0 0 1. (3) The risk factors of macrovascular complications in patients with NIDDM were HBs duration, smoking, and family history of HBP with RR values of 1 384, 2 6 18 and 1 995, respectively (P 0 05). The antihypertensive treatment and dietary control were protective factors, with RR values of 0 533 and 0 70 2 respectively (P 0 01). The risk factors for HBP in patients with NIDDM were family history of HBP, RR = 1 347, P <0 05. Good glycemic control for protective factors RR = 0 4 57, P <0 0 1. Conclusion In prevention and education of NIDDM, we should focus on the elderly, obesity, family history and previous history of HBP