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目的观察丝裂霉素Ｃ在青光眼滤过术中的应用效果。方法将青光眼施行小梁切除术４６只眼随机分为观察组及对照组各２３只眼。观察组用含有０２ｍｇ／ｍｌ浓度丝裂霉素Ｃ棉片，在巩膜瓣下及Ｔｅｎｏｍ’ｓ囊下贴敷５ｍｉｎ。对照组按常规手术方法。结果术后随访３～２８个月，观察组术后眼压控制率在９１％，功能性滤过泡占９１％。对照组术后眼压控制率为５７％，功能性滤过泡占５２％。经统计学处理有显著性差异（Ｐ＜００１）。结论丝裂霉素Ｃ能明显抑制球结膜下成纤维细胞的增生，促进滤过泡的形成，提高手术成功率。
Objective To observe the effect of mitomycin C in glaucoma filtration surgery. Methods 46 eyes of trabeculectomy under glaucoma were randomly divided into observation group (23 eyes) and control group (23 eyes). The observation group was treated with mitomycin C cotton at a concentration of 0.2 mg / ml and sutured under the scleral flap and under the Tenom’s capsule for 5 min. Control group according to conventional surgical methods. Results The patients were followed up for 3 to 28 months. The intraocular pressure (IOP) control rate in the observation group was 91% and functional filtration bleb was 91%. The control group postoperative intraocular pressure control rate was 57%, functional filtration bleb accounted for 52%. Statistically significant difference (P <0 01). Conclusion Mitomycin C can significantly inhibit the proliferation of subconjunctival fibroblasts, promote the formation of filtration bleb and improve the success rate of surgery.