论文部分内容阅读
瑞香烷型二萜类天然产物拥有5/7/6三环骨架的复杂分子结构,含有多个手性中心,通常在C3、C4、C5、C9、C13、C14、C20等位置含有手性羟基;其中,诸多化合物在C9、C13、C14位置的手性羟基之间形成特定的原酸酯结构.该类天然产物在抗HIV、抗癌、抗白血病、亲神经性、杀虫、细胞毒性等方面显示显著的生物活性.瑞香烷型的密集的高氧化数的多环骨架和其引人注目的生物活性吸引了众多研究者的合成兴趣,尽管迄今为止成功的全合成报道依然鲜见,但合成化学家对其多环骨架的构建已发展了大量有益的策略和方法,在此对相关合成工作进行归纳综述.
Diorganoid diterpenoid natural products have a complex molecular structure with a 5/7/6 tricyclic backbone and contain a number of chiral centers, often containing chiral hydroxyl groups at positions C3, C4, C5, C9, C13, C14, C20 ; Among them, a number of compounds in the C9, C13, C14 position of the chiral hydroxyl formed between the specific orthoester structure of these natural products in the anti-HIV, anti-cancer, anti-leukemia, neuroticism, insecticidal, cytotoxic Shows a significant biological activity.Randarin type of dense high oxidation number of the polycyclic backbone and its attractive biological activity has attracted the interest of many researchers in the synthesis, although the successful so far reported fully synthetic still rare, Synthetic chemists have developed a number of useful strategies and methods for the construction of their polycyclic frameworks. In this review, the synthesis of the work is summarized.