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目的观察雷公藤多甙对糖尿病肾病的治疗效果和安全性。方法糖尿病肾病患者42例随机分为两组:对照组20例,给予糖尿病常规治疗;试验组22例,在常规治疗的基础上加用雷公藤多甙片。测定治疗前后24-h尿蛋白定量、血清白蛋白(Alb)、血清肌酐(SCr)和血尿素氮(BUN)水平。结果治疗前,两组患者24-h尿蛋白、Alb、SCr和BUN比较差异均无统计学意义(P>0.05)。治疗后,治疗组的24-h尿蛋白、SCr和BUN表达均较治疗前降低(P<0.05),而血清Alb升高(P<0.05)。对照组上述指标治疗前后差异均无统计学意义(P>0.05)。两组均无明显不良反应。结论对于糖尿病肾病的患者在给予降糖、降压等综合治疗的基础上,加用雷公藤多甙片可有效改善糖尿病肾病患者的肾脏功能。
Objective To observe the therapeutic effect and safety of tripterygium wilfordii glycosides on diabetic nephropathy. Methods Forty-two patients with diabetic nephropathy were randomly divided into two groups: control group (20 cases) and conventional diabetes treatment group (22 cases). Tripterygium glycosides tablets were added on the basis of routine treatment. Serum albumin (Alb), serum creatinine (SCr) and blood urea nitrogen (BUN) levels were measured before and 24 hours after treatment. Results Before treatment, 24-h urinary protein, Alb, SCr and BUN had no significant difference between the two groups (P> 0.05). After treatment, the expressions of 24-h urinary protein, SCr and BUN in treatment group were lower than those before treatment (P <0.05), while serum Alb increased (P <0.05). There was no significant difference in the above indexes before and after treatment in the control group (P> 0.05). No significant adverse reactions in both groups. Conclusion For patients with diabetic nephropathy given glycemic, antihypertensive and other comprehensive treatment based on the addition of tripterygium glycosides tablets can effectively improve the diabetic nephropathy kidney function.