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黑色素瘤是起源于皮肤黑素瘤细胞的一种恶性肿瘤,对传统放化疗高度抵抗,目前还无有效的治疗方法。与其他种类肿瘤相比,黑色素瘤干细胞在瘤组织中所占比例更高,但由于没有发现特异性的黑色素瘤干细胞标记物,而且在肿瘤不同发展阶段黑色素瘤干细胞表面的标记物不断变化,使得以黑色素瘤干细胞为治疗靶点的研究陷入窘境。本篇文献将综述黑色素瘤干细胞的定义,起源,分子表面标记物以及相关问题的研究进展,以期为进一步的研究提供帮助与支持。
Melanoma is a malignant tumor originated from cutaneous melanoma cells, which is highly resistant to traditional radiotherapy and chemotherapy. Currently, there is no effective treatment. Compared with other types of cancer, melanoma stem cells account for a higher proportion of the tumor tissue, but because no specific markers of melanoma stem cells are found, and the markers on the surface of melanoma stem cells are constantly changing at different stages of the tumor, The study of melanoma stem cells as a therapeutic target is in a dilemma. This paper reviews the progress of melanoma stem cell definition, origin, molecular surface markers and related issues, with a view to providing help and support for further research.