目的:考察及胶软膏的体外释放度,为优化处方、制备工艺、合理用药提供依据。方法:用无水葡萄糖为对照品,以白及多糖为指标,生理盐水为释放介质,0.2%蒽酮-硫酸试液为染色剂,采用透析袋法研究及胶软膏的体外释药特性。结果:4 h内白及多糖累积释放度为61.8%,为速释期;在12 h以后药物的释放度为38.2%,为缓释期;48 h内累积释放度为97.8%。结论:及胶软膏具有缓释性,每12 h使用一次可保持疗效。该方法用于及胶软膏的体外释放度考察,操作便利、方法稳定、结果可靠。 OBJECTIVE: To investigate the in vitro release of gel ointment and provide basis for optimizing prescription, preparation process and rational drug use. Methods: Using anhydrous glucose as reference substance, white and polysaccharide as index, physiological saline as releasing medium, 0.2% anthrone-sulfuric acid test solution as stain, dialysis bag method and in vitro release characteristics of ointment were studied. Results: The cumulative release of white and polysaccharides was 61.8% within 4 h. The release rate was 38.2% after 12 h. The release rate was 97.8% within 48 h. Conclusion: Gum ointment has sustained release, which can be used every 12 hours to maintain the curative effect. The method is applied to investigate the in vitro release of the ointment and is convenient to operate, the method is stable and the result is reliable.