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目的 观察倍他乐克治疗冠心病及合并糖耐量异常时对糖、脂代谢的影响及量、效关系。方法 口服倍他乐克初始剂量 6 .2 5mg ,每日 2次 ,每 3天递增 6 .2 5～ 12 .5mg ,至达到最佳有效治疗剂量 ,维持用药 6个月。结果 倍他乐克临床最佳有效治疗剂量范围为 12 .5～ 10 0mg d ,应用 6个月后测血糖、血脂、胰岛素分泌水平与用药前比较无变化 (P >0 .0 5 )。结论 国人倍他乐克的有效治疗剂量远小于国外。此剂量范围长期应用于冠心病人及合并糖耐量异常者同样安全、有效 ,不引起糖、脂代谢的紊乱。
Objective To observe the effect of Betaloc on the metabolism of carbohydrate and lipid and the relationship between quantity and effect in the treatment of coronary heart disease and impaired glucose tolerance. Methods The initial dose of oral metoprolol 6.22mg, 2 times a day, every 3 days increased by 6.52 ~ 12.5mg, to achieve the best effective therapeutic dose, maintenance medication for 6 months. Results The best effective dose of metoprolol was 12.5 ~ 10 0 mg daily. Blood glucose, blood lipid and insulin secretion were not changed at 6 months after application (P> 0.05). Conclusion Chinese Betaloc effective dose is much smaller than abroad. Long-term application of this dose range in patients with coronary heart disease and patients with impaired glucose tolerance is equally safe and effective, does not cause sugar, lipid metabolism disorders.