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(1) 本实验比较了一些正常组织与癌瘤组织中谷氨酰胺酶活性。结果发现移植性癌瘤的酶活性以淋巴肉瘤最高。肿瘤间酶活性的变动范围不如正常组织间的变动范围大。诱发性淋巴肉瘤的酶活性较其来源组织为高,但皮肤癌则较正常表皮低。(2) 在肿瘤生长过程中,谷氨酰胺酶活性随肿瘤的重量而有所变化,如艾氏腹水癌(实质型)、脑瘤22、胸腺淋巴肉瘤等的谷氨酰胺酶活性有随肿瘤生长而升高的趋势,但这并不是肿瘤的一般规律,如脑瘤53、Walker癌、肉瘤180等则无此现象。(3) 再生肝的谷氨酰胺酶活性较正常肝低。(4) 讨论了谷氨酰胺酶与某些肿瘤生长的可能关系。
(1) This experiment compared glutaminase activity in some normal tissues and cancerous tissues. As a result, it was found that the enzymatic activity of transplanted carcinoma was highest in lymphosarcoma. The range of changes in the activity of tumors between tumors is not as large as that between normal tissues. The enzymatic activity of induced lymphosarcoma is higher than that of its source tissue, but skin cancer is lower than normal epidermis. (2) In the process of tumor growth, glutaminase activity changes with the weight of the tumor, such as Ehrlich ascites carcinoma (parenchymal), brain tumor 22, thymic lymphosarcoma and other glutaminase activity with the tumor The trend of growth is elevated, but this is not a general rule of the tumor. For example, brain tumor 53, Walker cancer, and sarcoma 180 do not have this phenomenon. (3) The glutaminase activity of regenerating liver is lower than that of normal liver. (4) Discusses the possible relationship between glutaminase and the growth of certain tumors.