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C—myc 致癌基因和一个免疫球蛋白位点的染色体易位,是小鼠和人类B 淋巴细胞肿瘤中一个极普遍现象.在C—myc 附近插入特定的反向病毒顺序能使C—mye 基因的表达明显增强,发生转化作用,从而可得出一个概念,即染色体易位于C—myc 基因的激活可能有类似效应。免疫球蛋白(Ig)基因转录的调节在Ig 基因表达特别是转录如何被调节的最新概念中,应考虑myc 基因易位致Ig 位点的可能后果。在B 淋巴细胞分化过程中,经过一系列DNA 重组产
Chromosomal translocation of the C-myc oncogene and an immunoglobulin site is a very common phenomenon in mouse and human B-lymphocyte tumors. Inserting a specific reverse viral sequence near C-myc can make the C-mye gene The expression was significantly enhanced and transformation occurred, which led to the notion that the activation of chromosomes in the C-myc gene may have similar effects. Regulation of the transcription of immunoglobulin (Ig) genes In the latest concept of Ig gene expression, in particular how transcription is regulated, the possible consequences of the Ig site resulting from the translocation of the myc gene should be considered. In the process of B lymphocyte differentiation, it undergoes a series of recombinant DNA production.