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目的观察秦皮甲素对高脂饮食诱导的实验性大鼠脂肪肝的防治作用。方法 48只SD大鼠,随机分为正常对照组、模型组、辛伐他汀组(5 mg.kg-1.d-1),秦皮甲素低剂量组(10 mg.kg-1.d-1)、中剂量组(30 mg.kg-1.d-1)、高剂量组(90 mg.kg-1.d-1)。高脂饲料饲养大鼠诱导脂肪肝,同时灌胃上述各组药物,连续12 wk。测定血浆三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)浓度;血浆、肝脏匀浆丙二醛(MDA)浓度,血浆亚硝酸根(NO2-)浓度和肝脏脂质蓄积情况。结果与模型组相比较,秦皮甲素低、中、高3个剂量组均可显著降低血浆TG、LDL的浓度(P<0.05),而对TC、HDL则无明显影响(P>0.05);同时,均可显著降低血浆MDA浓度(P<0.05);秦皮甲素中、高2个剂量组显著降低肝脏MDA浓度(P<0.05),而对血浆NO2-无明显影响(P>0.05)。病理切片显示秦皮甲素显著降低脂质在肝脏的蓄积。结论秦皮甲素对实验性脂肪肝有一定的防治作用。
Objective To observe the effect of aesculin in the prevention and treatment of fatty liver induced by high-fat diet in rats. Methods 48 SD rats were randomly divided into normal control group, model group, simvastatin group (5 mg.kg-1.d-1), aesculin low dose group (10 mg.kg-1.d- 1), middle dose group (30 mg.kg-1.d-1) and high dose group (90 mg.kg-1.d-1). Fat-fed rats were fed with high-fat diet to induce fatty liver, and the above groups of drugs were given simultaneously for 12 weeks. Plasma triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) were measured. Plasma and liver homogenate concentrations of malondialdehyde (MDA), plasma nitrite NO2-) concentration and liver lipid accumulation. Results Compared with the model group, the plasma concentration of triglyceride in low, medium and high doses of aesculin decreased significantly (P <0.05), but had no significant effect on TC and HDL (P> 0.05). (P <0.05). In the aesculin group, the high and low dose groups of 2 doses significantly reduced the MDA content in the liver (P <0.05), but had no effect on the plasma NO2 - level (P> 0.05). Pathological sections showed that aesculin significantly reduced lipid accumulation in the liver. Conclusions Aesculin has some preventive and therapeutic effects on experimental fatty liver.