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肿瘤细胞对紫杉醇产生耐药是一个多途径过程，除多药耐药外，还与微管蛋白亚型表达的改变、微管相关蛋白的缺失以及微管蛋白聚合力受损等因素有关。本文就近年来这方面的研究进展作一综述。
In addition to multidrug resistance, tumor cells are multi-pathogenic to paclitaxel resistance, which is also related to the changes of the expression of the tubulin subtype, the deletion of the microtubule-associated protein, and the impaired tubulin polymerization ability. This article summarizes the research progress in this area in recent years.