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目的:讨论血液灌流联合床边血液净化对重症中毒的治疗效果。方法:以2014年1月至2016年6月英德市人民医院收治的16例重症中毒患者为研究对象。入院后,所有患者均予以传统的治疗方法,如洗胃、解毒药物、利尿、保护重要脏器功能外,征得家属同意行血液灌流及床边血液净化。观察治疗后12 h、24 h、48 h、72 h肝肾功能变化及治疗后转归。结果:治疗12 h、24 h、48 h、72 h后,患者血肌酐、总胆红素及谷丙转氨酶呈下降趋势。15例患者病情好转出院,治愈率93.75%。结论:重症中毒患者在传统的抢救治疗的基础上予床边血液灌流+血液净化序贯治疗,可减少多器官功能衰竭,提高抢救治愈率,减少临床死亡率。
Objective: To discuss the therapeutic effect of hemoperfusion and bedside blood purification on severe poisoning. Methods: From January 2014 to June 2016, 16 cases of severe poisoning patients admitted to Yingde People’s Hospital were studied. After admission, all patients were given traditional treatment methods, such as gastric lavage, detoxification drugs, diuretic, protection of vital organs, the consent of the family agreed to hemoperfusion and bedside blood purification. The changes of liver and kidney function at 12 h, 24 h, 48 h, 72 h after treatment were observed and the outcomes after treatment were observed. Results: Serum creatinine, total bilirubin and alanine aminotransferase decreased after treatment for 12 h, 24 h, 48 h and 72 h. 15 patients improved condition and discharged, the cure rate was 93.75%. Conclusion: Severe poisoning patients in the traditional rescue treatment based on bedside hemoperfusion + blood purification sequential treatment can reduce multiple organ failure, improve the cure rate and reduce the clinical mortality.