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目的:对HIV感染者口腔黏膜乳头状瘤病毒(HPV)感染进行研究,并对比其中女性宫颈的感染状况,了解湖北地区HIV感染者口腔内HPV感染的流行和分布,证实HPV与HIV之间及相关疾病的相互关系。方法:收集40例自愿接受检查的HIV感染者的一般情况,检测其CD4+T细胞计数,并对受检者中的女性进行宫颈检测,使用PCR方法检测口腔及宫颈处HPV亚型,采用SPSS 17.0软件进行统计分析。结果:有1例(2.5%)患者检测出口腔HPV52型,10例女性患者(38.5%)在宫颈黏膜样本中检测出HPV感染,且有2例同时检测出2种以上HPV基因型。结论:HIV感染者口腔内HPV感染率远低于宫颈黏膜HPV感染率,两区域间HPV感染状况没有明显联系。
OBJECTIVE: To study the infection of oral mucosal papilloma virus (HPV) in HIV-infected patients and to compare the prevalence of cervical infection among female HIV-infected patients and the prevalence and distribution of HPV infection in HIV-infected persons in Hubei Province, Related diseases. Methods: The general situation of 40 HIV-infected patients who were volunteered to be tested were collected, the CD4 + T cell count was measured, and the women in the subjects were tested for cervical cancer. PCR was used to detect the HPV subtypes in oral cavity and cervix. SPSS 17.0 software for statistical analysis. Results: HPV type 1 was detected in 1 patient (2.5%) and HPV infection in cervical mucosa in 10 women (38.5%). Two HPV genotypes were detected in 2 patients at the same time. Conclusion: The infection rate of HPV in oral cavity of HIV-infected persons is much lower than that of HPV infection of cervical mucosa. There is no obvious correlation between HPV infection in the two regions.