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本研究首次采用放射免疫分析法（ＲＩＡ）对２８例格林一巴利综合征（ＧＢＳ）患儿急性进展期及恢复期血清和脑脊液中肿瘤坏死因子α（ＴＮＦα）进行动态观察。结果表明：急性期血清中ＴＮＦα水平升高明显，随着病情的恢复ＴＮＦα水平下降。急性期及恢复期脑脊液中ＴＮＦα水平均升高明显，下降缓慢，且与病变累及部位无关，与同一时间血中ＴＮＦα水平不相关（ｒ≈０，Ｐ＞０．０５）。提示ＧＢＳ是一种免疫功能障碍性疾病，ＴＮＦα是其主要致病因素之一，脑脊液中ＴＮＦα的存在，有力地支持了人类神经系统中存在产生ＴＮＦα细胞这一学说。
In this study, the first time using radioimmunoassay (RIA) in 28 cases of Guillain-Barre syndrome (GBS) children with acute progressive and convalescent serum and cerebrospinal fluid tumor necrosis factor α (TNFα) dynamic observation. The results showed that TNFα levels in serum increased significantly during acute phase, and TNFα level decreased with the recovery of disease. The levels of TNFα in cerebrospinal fluid in acute and convalescent phase were significantly increased and decreased slowly, and had no relation with the affected site of tumor. There was no correlation between TNFα and blood TNFα (r 0 0, P> 0.05) at the same time. Prompt GBS is an immune dysfunction disease, TNFα is one of its major causative factors, the presence of TNFα in cerebrospinal fluid, effectively supporting the human nervous system in the production of TNFα cells in this doctrine.