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目的:探讨胶囊微量法~(14)C-尿素呼气试验(~(14)C-UBT)用于诊断幽门螺杆菌感染及评价疗效中的应用。方法:将92例有反复腹痛患儿进行三种方法检验HP,其中病理组织学切片、HM—CAP检测、快速尿素酶检测三种方法中二项阳性认为有HP感染,同时作胶囊微量法~(14)C-尿素呼气试验,并将二者均为阳性55例反复腹痛患儿随机分为治疗组(27例)和安慰组(28例),接受雷尼替丁、胶体次枸橼酸铋、呋喃唑酮三联治疗,疗程四周,停药四周后随访。结果:92例反复腹痛患儿HP感染率为63.04％,胶囊微量法~(14)C-UBT检测HP阳性率为61.96％,其敏感性、特异性、准确性、阳性预测值、阴性预测值均在90～100％之间,三联治疗后治疗组与安慰组腹痛治疗总有效率分别为93.6％和21.4%,HP转阴率分别为85.2％和7％,两组差异有显著性。结论:~(14)C-UBT具有方法简单,准确性高,无损伤、污染小等优点,适用于儿童HP感染诊断及治疗的疗效判定。三联治疗反复腹痛儿童HP感染临床效果好,HP根除率高,值得在临床推广应用。
OBJECTIVE: To investigate the application of the microcirculation ~ (14) C-urea breath test (~ (14) C-UBT) in the diagnosis of Helicobacter pylori infection and evaluate the curative effect. Methods: Ninety-two children with recurrent abdominal pain were tested for HP in three ways. Among them, two of the three methods of histopathological examination, HM-CAP test and rapid urease test were positive for HP infection, (14) C-urea breath test, and both were positive in 55 cases of recurrent abdominal pain were randomly divided into treatment group (27 cases) and comfort group (28 cases) received ranitidine, colloidal sub-citron Bismuth, furazolidone triple therapy, treatment for four weeks, four weeks after drug withdrawal. Results: The HP infection rate was 63.04% in 92 cases of recurrent abdominal pain, and the positive rate of HPC was (14.9) 61.96% by C-UBT. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value All of them were between 90% and 100%. The total effective rates of treatment of abdominal pain in treatment group and comforted group after triple therapy were 93.6% and 21.4%, respectively. The negative conversion rates of HP were 85.2% and 7% respectively. There was significant difference between the two groups. Conclusion: The 14 C-UBT has the advantages of simple method, high accuracy, no damage and little pollution and is suitable for the diagnosis and treatment of children’s HP infection. Triple treatment of recurrent abdominal pain in children with HP infection clinical effect is good, HP eradication rate is high, it is worth in the clinical application.