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采用Ｔｉｍｍ＇ｓ组化法，电镜下观察了缺Ｚｎ幼年大鼠海马亚细胞水平Ｚｎ的分布和反应颗粒数目的变化。结果：Ｚｎ浓集分布于正常大鼠海马苔藓纤维终末的囊泡内，在突触间隙内也见有Ｚｎ存在；缺Ｚｎ状态下，海马神经元亚细胞水平Ｚｎ反应颗粒数目明显减少。本实验从一定程度证明了：①海马神经元的Ｚｎ参与神经元的递质释放调节与兴奋传递过程；②缺Ｚｎ海马苔藓纤维终末囊泡内Ｚｎ的丢失，可能是引起海马Ｚｎ的灰度值降低和发生一系列功能变化的关键。
Timm’s histochemical method was used to observe the distribution of Zn and the number of reactive particles in the hippocampal subfamily of Zn deficient rats. RESULTS: Zn concentration was distributed in the vesicles of the terminal mossy fiber of hippocampus in normal rats, and Zn was found in the synaptic cleft. In the absence of Zn, the number of Zn-responsive particles in hippocampal neurons decreased significantly. This experiment to some extent proved: ① Zn in hippocampal neurons involved in neurotransmitter release regulation and excitatory transmission process; ② lack Zn Zn hippocampal moss fiber end-vesicle loss may be caused by hippocampal Zn gray The key to lowering values and making a series of functional changes happen.