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目的：探讨乙型病毒性肝炎（乙肝）患者外周血淋巴细胞亚群及膜表面白细胞介素２受体（ｍＩＬ－２Ｒ）与乙肝发病机制的关系．方法：采用ＡＰＡＡＰ技术检测９２例慢性乙肝患者外周血淋巴细胞亚群及ｍＩＬ－２Ｒ．结果：慢性乙肝患者ＣＤ＋４细胞数明显降低（Ｐ＜０．０５），ＣＤ＋８细胞数显著上升（Ｐ＜０．０５或Ｐ＜０．０１），以致ＣＤ＋４／ＣＤ＋８比值下降；ｍＩＬ－２Ｒ显著低于正常对照组（Ｐ＜０．０５），在ＰＨＡ激活后与正常接近，但均较ＰＨＡ激活前显著增高（Ｐ＜０．０１）．２０例慢活肝恢复期ｍＩＬ－２Ｒ已趋于正常．结论：慢性乙肝患者存在着免疫调节功能异常，可能与乙型肝炎病毒的持续存在互为因果关系．
Objective: To investigate the relationship between the peripheral blood lymphocyte subsets and the membrane surface interleukin-2 receptor (mIL-2R) in patients with hepatitis B and the pathogenesis of hepatitis B. Methods: The peripheral blood lymphocyte subsets and mIL-2R in 92 patients with chronic hepatitis B were detected by APAAP technique. Results: The number of CD + 4 cells was significantly decreased (P <0.05), the number of CD + 8 cells was significantly increased in patients with chronic hepatitis B (P <0.05 or P <0.01), and the ratio of CD + 4 / CD + The normal control group (P <0.05), PHA activation and normal close, but were significantly higher than PHA before activation (P <0.01). 20 cases of slow liver recovery mIL-2R has become normal. Conclusion: There are immunomodulatory dysfunction in patients with chronic hepatitis B, which may be causally related to the persistence of hepatitis B virus.