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用不同浓度的PbO_2尘给大鼠气管注入,发现0.02~0.05mg/m~3引起动物血铅水平、全血δ-ALAD活力、肝微粒体P-450含量的改变,脏器中有铅蓄积。0.005mg/m~3引起血铅轻度升高。0.0015mg/m~3未引起任何指标改变。
Different concentrations of PbO 2 dust were injected into the trachea of rats, and it was found that 0.02 ~ 0.05 mg / m 3 caused changes of blood lead level, δ-ALAD activity in whole blood, P-450 content in liver microsome, . 0.005mg / m ~ 3 caused a slight increase in blood lead. 0.0015mg / m ~ 3 did not cause any change in the index.