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采用小白鼠尾静脉注射给药途径 ,按照 Bliss法 ,测定蚯蚓素的 L D50 为 2 914 .74mg/kg,其 95 %可信限为 3 2 3 6 .6 8～ 2 6 2 4.82 mg/kg。表明蚯蚓素作为肌肉注射或静脉注射药物具有一定的安全性
Using a mouse tail vein injection route, according to the Bliss method, the L D50 of alizarin was determined to be 2 914.74 mg/kg, with a 95% confidence limit of 3 2 3 6 . 6 8 to 2 62 4.82 mg/kg. . Shows that alizarin has certain safety as an intramuscular or intravenous drug