PPAR-γ激动剂作为胰岛素增敏剂除能降低血糖及增加胰岛素敏感性外,还在脂质代谢、抑制细胞因子、抗炎、免疫调节和血压调节等方面起着关键作用。近来研究发现过氧化物酶体增殖物激活受体激动剂对糖尿病肾病有一定的保护作用,本文就其对糖尿病肾病保护作用及机制简要综述。 PPAR-γ agonists, as insulin sensitizers, play a key role in lipid metabolism, cytokine suppression, anti-inflammatory, immune regulation and blood pressure regulation in addition to lowering blood glucose and increasing insulin sensitivity. Recent studies have found that peroxisome proliferator-activated receptor agonists have some protective effect on diabetic nephropathy, this article on its role in the protection of diabetic nephropathy and a brief review of the mechanism.