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目的:探讨纤溶酶原激活物抑制物-1(PAI-1)基因多态性与2型糖尿病(T2DM)患者冠状动脉粥样硬化性(CHD)的关系。方法:对50例单纯T2DM患者、30例T2DM合并冠心病患者进行ACE基因、PAI-l基因多态性检测,分析影响T2DM患者冠心病的危险困素。结果:T2DM合并冠心病和PAI-1基因型密切相关。结论:Pal-1基因多态性可能是T2DM患者合并冠心病的危险因索。
Objective: To investigate the relationship between plasma PAI-1 gene polymorphism and coronary atherosclerosis (CHD) in type 2 diabetes mellitus (T2DM). Methods: ACE gene and PAI-1 gene polymorphisms were detected in 50 T2DM patients and 30 T2DM patients with coronary heart disease. The risk factors affecting coronary heart disease in patients with T2DM were analyzed. Results: T2DM with coronary heart disease and PAI-1 genotypes are closely related. Conclusion: The polymorphism of Pal-1 gene may be the risk factor of coronary heart disease in T2DM patients.