论文部分内容阅读
本文探讨了外用新中成药速肤保的主要药效及安全性。实验结果表明:速肤保具有如下药理作用:1.对创伤感染常见的病原菌和条件致病菌均有不同程度的抗菌作用;2.有一定的抗炎作用。能抑制巴豆油混合致炎液所致的小鼠耳肿胀,抑制大鼠蛋清性足肿胀,对二甲苯所致小鼠毛细血管通透性增高有拮抗作用,能减少小鼠烫伤组织的含水量;3.有一定的镇痛作用。能抑制醋酸所致的小鼠扭体反应,提高小鼠痛阈,减轻热刺激所致的疼痛;4.有一定的止血作用。能缩短小鼠的出血时间。实验还证明,速肤保对小鼠无明显毒性作用,对新西兰大白兔正常及损伤皮肤均无明显刺激性,对豚鼠皮肤亦未产生过敏反应。本实验结果为速肤保的有效性和安全性提供了一定的药理学依据。
This article discusses the main efficacy and safety of the topical new Chinese patent drug Yuesaobao. The experimental results show that: fast skin Paul has the following pharmacological effects: 1. Common pathogenic bacteria and conditional pathogens of wound infection have different degrees of antibacterial effect; 2. Have a certain anti-inflammatory effect. It can inhibit the swelling of mouse ears caused by croton oil mixed with inflammatory solution, inhibit the swelling of rat egg whites, and has an antagonistic effect on the increase of capillary permeability of mice induced by xylene, and can reduce the water content of mouse scald tissue. ; 3. There is a certain degree of analgesic effect. Can inhibit the acetic acid-induced writhing in mice, increase the pain threshold in mice, and reduce the pain caused by thermal stimulation; 4. Have a certain role in hemostasis. It can shorten the bleeding time of mice. The experiment also proved that there is no obvious toxic effect of fast skin protection on mice, no obvious irritation to normal and damaged skin of New Zealand white rabbits, and no allergic reaction to guinea pig skin. The results of this experiment provide a certain pharmacological basis for the effectiveness and safety of quick skin protection.