氟是自然环境中广泛分布且与人体健康密切相关的微量化学元素之一,对人体健康影响具有双重性,摄入不足或过量均可对人体产生不良影响。如果氟摄入量不足,可导致龋齿患病率升高[1];当经各种途径长期摄入过量氟,又可引起以氟骨症和氟斑牙为主要特征的一种慢性全身性疾病,即地方性氟中毒,又称地方性氟病[2]。地方性氟中毒在世界各国均有报道, Fluorine is one of trace chemical elements widely distributed in the natural environment and closely related to human health. It has dual effects on human health. Inadequate or excessive intake of fluoride can have adverse effects on the human body. If insufficient fluoride intake can lead to an increased prevalence of caries [1], chronic overdose of fluoride through various means may cause a chronic general condition characterized by skeletal fluorosis and dental fluorosis Disease, endemic fluorosis, also known as endemic fluorosis [2]. Local fluorosis is reported in all countries in the world,