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目的观察阿昔莫司胶囊联合绞股蓝总甙片治疗以甘油三酯升高为主的混合型高脂血症的疗效。方法 36例以甘油三酯升高为主的混合型高脂血症患者,随机分成治疗组及对照组,各18例。治疗组应用阿昔莫司胶囊联合绞股蓝总甙片治疗,对照组应用辛伐他汀片治疗。观察比较两组治疗效果及不良反应发生情况。结果治疗前,两组患者的甘油三酯、总胆固醇、低密度脂蛋白胆固醇比较,差异均无统计学意义(t=0.177、0.033、0.309,P>0.05);治疗后,治疗组的甘油三酯低于对照组,差异具有统计学意义(t=2.949,P<0.05);两组患者的总胆固醇及低密度脂蛋白胆固醇比较,差异均无统计学意义(t=0.244、0.315,P>0.05)。治疗后,治疗组2型糖尿病患者的空腹血糖(6.5±1.4)mmol/L低于对照组2型糖尿病患者(8.0±1.7)mmol/L,差异具有统计学意义(P<0.05)。治疗组无一例发生不良反应,对照组发生1例(5.6%),两组比较差异无统计学意义(P>0.05)。结论阿昔莫司胶囊联合绞股蓝总甙片治疗以甘油三酯升高为主的混合型高脂血症疗效确切,并使糖尿病合并混合型高脂血症患者的血糖降低。
Objective To observe the curative effect of acipimox combined with gypenosides in the treatment of mixed hyperlipidemia, which is mainly composed of triglycerides. Methods Thirty-six patients with mixed hyperlipidemia, which were mainly elevated in triglycerides, were randomly divided into treatment group and control group, with 18 cases in each group. The treatment group was treated with acipimox capsules combined with gypenosides tablets, and the control group was treated with simvastatin tablets. Observation and comparison of two groups of treatment and adverse reactions occurred. Results Before treatment, there was no significant difference in triglyceride, total cholesterol and low-density lipoprotein cholesterol between the two groups (t = 0.177,0.033,0.309, P> 0.05). After treatment, triglyceride (T = 2.949, P <0.05). There was no significant difference in total cholesterol and LDL cholesterol between the two groups (t = 0.244,0.315, P> 0.05). After treatment, the fasting blood glucose (6.5 ± 1.4) mmol / L was lower in the treatment group than in the control group (8.0 ± 1.7) mmol / L for type 2 diabetes mellitus (P <0.05). No adverse reactions were found in the treatment group, 1 case (5.6%) in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion Acmiculil capsules combined with Gypenosides tablets treatment of hypertriglyceridemia with hyperlipidemia is effective, and diabetes mellitus patients with mixed hyperlipidemia decreased blood glucose.