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脱发是阿霉素(Adriamycin)常见的副作用,对许多患者来说,脱发也是化疗中使人畏惧的一种症状,因而许多患者不愿意接受化疗。作者对采用阿霉素治疗的病人,给予维生素E1,600IU/d进行了预防脱发的研究,在16例可以评价的患者中,只有5例发生脱发,其他患者只是有轻度或中度脱发而不需要戴帽子或用假发。作者的经验是,在首次应用阿霉素之前给予维生素E的时间和以后发生脱发有关。在5例脱发的患者中,3例给予维生素E的时间是在首次用阿霉素前72小时之内。大多数服用维生素E时间较长的患者则不发生脱发,故作者认为在化疗开始前给予维生素E5～7天最好。
Hair loss is a common side effect of Adriamycin. For many patients, hair loss is a fearful symptom in chemotherapy, and many patients are reluctant to undergo chemotherapy. The authors conducted a study on prevention of hair loss with vitamin E 1,600 IU/d in patients treated with doxorubicin. Of the 16 patients who could be evaluated, only 5 had hair loss. Others only had mild or moderate hair loss. No hat or wig is required. The author’s experience is that the timing of vitamin E administration prior to the first application of doxorubicin is associated with hair loss occurring later. In 5 patients with hair loss, 3 patients were given vitamin E within 72 hours before the first use of doxorubicin. Most patients who take vitamin E for a long time do not have hair loss. Therefore, the author believes that it is best to give vitamin E for 5 to 7 days before the start of chemotherapy.