论文部分内容阅读
病毒感染是二十一世纪面临的主要医学挑战之一,从影响全球3%人口的丙肝病毒(HCV)流行病到最近爆发的西尼罗河病毒、寨卡病毒和埃博拉病毒感染。病毒缺乏进行自我复制所需的基础代谢机制。为了解决这个问题,它们劫持它们的宿主的代谢机制以便完成它们的生命周期和进行增殖。然而,科学家们仍然并没有很好地理解病毒与它们感染的有机体之间在代谢上的相互作用。这主要是因为人基因与代谢过程之间存在复杂的相互作用。
Viral infection is one of the major medical challenges in the twenty-first century, with the recent outbreak of West Nile virus, Zika virus and Ebola virus infections from the hepatitis C virus (HCV) epidemic affecting 3% of the world’s population. The virus lacks the underlying metabolic mechanisms needed for self-replication. To solve this problem, they hijack their host’s metabolism in order to complete their life cycle and to proliferate. However, scientists still do not have a good understanding of the metabolic interactions between the virus and the organism to which they are infected. This is mainly due to the complex interactions between human genes and metabolic processes.