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来自同一祖先的两株不同亚克隆细胞系Ｈｃａ－１６Ａ３－Ｆ（Ｆ）和ＨＣａ－Ａ２－Ｐ（Ｐ），在两种不同小鼠体内经不同途径接种所得的转移率和转移部位显示有差别：Ｃ３／ｈｅ小鼠皮下组，Ｆ呈现高淋巴道转移（８０．０％），而Ｐ未出现转移，Ｃ３Ｈ／ｈｅ小鼠尾静脉组，Ｆ在卵巢（２８．６％）和淋巴结（２８．６％）有较低的转移率，Ｐ权出现一例（１４．３％）卵巢转移，然而，在裸鼠体内却出现了异常的变化，Ｆ呈现高血道（肺脏７１．４％）转移而不出现淋巴道和其他部位转移，但Ｐ却出现高淋巴道转移（８５．７％）兼有低血道（肺脏２８．６％，卵巢１４．３％，肾脏２８．６％）转移。体内实验结果提示：ＨＣａ细胞中含有转移、浸润能力不同的亚群；Ｆ细胞在体内具有较强的浸润力与转移力，且有淋巴道转移的倾向；Ｐ细胞的浸润力和转移力则低于Ｆ细胞，但若给其提供适当的到达器官的通路，完全能形成实验性转移灶。Ｃ３Ｈ／ｈｅ小鼠也是ＨＣａ细胞生长和转移的理想宿主。
Two different subcloned cell lines Hca-16A3-F(F) and HCa-A2-P(P) from the same ancestor showed different rates of metastasis and metastasis in two different mouse inoculations by different routes : In the subcutaneous group of C3/he mice, F showed high lymphatic metastasis (80.0%), while P did not appear metastasis, C3H/he mouse tail vein group, F in the ovary (28.6%) and lymph nodes (28 (6%) had a low rate of metastasis. A P power showed a case (14.3%) of ovarian metastasis. However, abnormal changes occurred in nude mice, and F showed a high bloodstream (71.4% of lung) metastasis. No lymphatic metastasis and other metastases occurred, but P had high lymphatic metastasis (85.7%) and low bloodstream (28.6% in lung, 14.3% in ovary, and 28.6% in kidney). The results of in vivo experiments suggest that HCA cells contain subpopulations with different metastasis and infiltration capabilities; F cells have strong infiltration and metastasis forces in the body and tend to have lymphatic metastasis; P cells have low infiltration and transfer For F cells, but if they are given appropriate access to organs, they can fully form experimental metastases. C3H/he mice are also ideal hosts for the growth and metastasis of HCa cells.