本文简要报道肾显像剂~(99m)Tc-MAG_3的合成、标记和动物实验。三甘氨酸与氯乙酰氯反应生成氯乙酰三甘氨酸,再与硫代苯甲酸钠生成苯甲酰巯乙酰三甘氨酸。后者溶于葡萄糖酸钠溶液中,pH为5.5。然后在N_2气流下加入氯化亚锡冷冻干燥制成药盒。应用前注入1—2ml(约148MBq)~(99m)TcO_4~-加热5min,标记率可达95％,动物实验证明安全、稳定;家兔显像清晰。 This article briefly reports the synthesis, labeling and animal experiments of renal imaging agent ~ (99m) Tc-MAG_3. Trichloroacetic acid and chloroacetyl chloride reaction of chloroacetyl triglycine, and sodium thiosulfate to generate benzoyl thioacetyl triglycine. The latter is dissolved in sodium gluconate solution and has a pH of 5.5. Then add stannous chloride freeze-dried under the N2 flow to make the kit. 1-2ml (about 148MBq) ~ (99m) TcO_4 ~ -heat 5min before application, the labeling rate can reach 95%, animal experiments proved safe and stable;