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[目的]探讨氯乙烯(VCM)接触工人体内氧化损伤指标的变化,筛选可能的氯乙烯接触效应生物标志物。[方法]以359名氯乙烯接触工人为接触组,158名不接触氯乙烯的工人为对照组,测定血清中超氧化物歧化酶(SOD)、丙二醛(MDA)以及谷胱甘肽硫转移酶(GST)的含量。[结果]多元线性回归分析结果显示,各VCM累积接触剂量组与对照组相比,SOD活性降低(P<0.001)而MDA活性增高(P<0.001)。低剂量组和高剂量组与对照组相比,GST水平增高(P<0.05)。趋势卡方检验结果显示,VCM累积接触剂量与SOD和GST活性间存在明显的剂量-反应关系。[结论]在目前的VCM接触浓度下,VCM可造成氧化损伤指标的改变。认为MDA、SOD、GST可作为VCM暴露评价的效应生物标志物。
[Objective] To explore the changes of oxidative damage in VCM exposed workers and screen possible bioactive markers of exposure to vinyl chloride. [Method] With 359 workers exposed to vinyl chloride as a contact group and 158 workers exposed to vinyl chloride as a control group, serum superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione S-transferase Enzyme (GST) content. [Results] The results of multivariate linear regression analysis showed that compared with the control group, the SOD activity decreased (P <0.001) and the MDA activity increased (P <0.001). Compared with the control group, GST level increased in low-dose group and high-dose group (P <0.05). The trend chi-square test showed that there was a significant dose-response relationship between the cumulative exposure dose of VCM and the activity of SOD and GST. [Conclusion] VCM can cause the change of oxidative damage index under the current VCM exposure concentration. It is considered that MDA, SOD and GST can be used as biomarkers of biomarker evaluation for VCM exposure.