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成纤维细胞生长因子(FGF)主要包括酸性FGF(aF-GF)和碱性FGF(bFGF),对多种细胞具有促进增殖和分化的功能,与肿瘤生长关系密切。本文采用RF-PCR方法,对肝癌中aFGF,bFGF及其受体FGRF_1的mRNA表达进行了研究。 临床资料:收集辽宁省肿瘤医院2001-02～2003-02期间30例肝癌手术切除的新鲜标本,其中男性21例,女性9例;年龄31～72岁,平均58.5岁。肝癌分级按WHO标准:高分化12例(40％),中分化9例(30％),低分化9例(30％)。TNM分期Ⅰ期2例(6.7％),Ⅱ期11例
Fibroblast growth factor (FGF) mainly includes acidic FGF (aF-GF) and basic FGF (bFGF), which can promote proliferation and differentiation of many kinds of cells and is closely related to tumor growth. In this paper, the mRNA expression of aFGF, bFGF and its receptor FGRF_1 in hepatocellular carcinoma was studied by RF-PCR. Clinical data: Thirty patients with liver cancer resected during 2001-02 ~ 2003-02 were collected, including 21 males and 9 females, aged from 31 to 72 years (average 58.5 years). Histopathological classification according to WHO criteria: well-differentiated in 12 cases (40%), moderately differentiated in 9 cases (30%), poorly differentiated in 9 cases (30%). TNM stage Ⅰ in 2 cases (6.7%), Ⅱ in 11 cases