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作者采用单克隆抗体的免疫指标和染色体组型的基因研究来作为鉴别急性白血病原始细胞的依据.通常大多数急淋(ALL)具有一种或多种阳性的 B 淋巴细胞限制性抗原,普通淋巴细胞白血病抗原(cALLA)和原始细胞核的末端脱氧核苷酸转移酶(TdT)阳性,符合以上特征者,可确定为前 B 细胞。而急非淋(ANLL)TdT 往往阴性,缺乏 B 淋巴细胞标记。作者报导两例女性 ANLL 病例,具有淋巴细胞的表现型。例1,10岁,肝肿大4cm,脾肿大14cm,伴有中枢神经系统白血病,Hb4g/dl,白细胞438000
The authors used monoclonal antibody immunoassay and karyotype genetic studies as the basis for identifying acute leukemia blast cells. Usually most acute lymphocytic (ALL) have one or more positive B lymphocyte-restricted antigens, common lymphoid The cell leukemia antigen (cALLA) and the terminal nuclear deoxynucleotidyl transferase (TdT) of the naive nucleus were positive and matched the above characteristics, and they were identified as pre-B cells. The acute non-lymphocytic (ANLL) TdT is often negative and lacks B lymphocyte markers. The authors report two cases of female ANLL with lymphocyte phenotype. Case 1, 10 years old, hepatomegaly 4cm, splenomegaly 14cm, with central nervous system leukemia, Hb4g/dl, WBC 438000