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目的 应用丁胺卡那霉素地塞米松(丁卡地塞)复方脂质体玻璃体内注射以延长两种药物的半衰期.方法 大白兔随机分4组,正常眼2组和眼内炎眼2组均分别注射复方脂质体和游离药物.结果 丁卡在正常眼复方脂质体的半衰期较游离药物延长1.8倍,在眼内炎眼延长3.4倍.地塞在正常眼复方脂质体半衰期较游离药物延长22.5倍,在眼内炎眼延长46.2倍.结论 丁卡地塞复方脂质体玻璃体内注射使丁卡和地塞两种药物的半衰期有明显延长.
Objective To observe the half-life of amikacin dexamethasone (D-Cefditoren) liposomes intravitreally in order to prolong the half-life of the two drugs.Methods Rabbits were randomly divided into 4 groups: normal eye 2 and intraocular eye 2 Group were injected with compound liposomes and free drugs respectively.Results The half-life of compound card liposomes in normal eyes was 1.8 times longer than that of free drugs and 3.4 times longer in the eyes of the eye.Effects of earth plug on the half life of compound liposomes in normal eyes 22.5 times longer than free drug and 46.2 times longer in intraocular inflammation.Conclusion Diclazepine liposomes intravitreal injection significantly prolonged the half-life of both Dinka and Dexamethasone.