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目的:观察131I标记的血管抑素在荷Lewis肺癌C57BL/6小鼠体内的放射受体显像,评价血管抑素及131I-血管抑素和单纯131I对小鼠Lewis肺癌移植瘤的治疗效果,探讨131I-血管抑素治疗实体瘤的临床应用前景。方法:①2001-02/05在第四军医大学唐都医院核医学实验室进行显像实验:用氯胺-T法进行131I标记,将标记产物131I-血管抑素从尾静脉注入荷Lewis肺癌的C57BL/6小鼠体内,用131I标记的白蛋白作为对照,分别于24,48,96,144h后进行ECT扫描。②2002-07/2003-02在该实验室进行治疗实验:28只荷Lewis肺癌的C57BL/6小鼠(右前肢皮下移植瘤直径约1cm)随机分成4组,分别腹腔注射131I-血管抑素(含131I11.1MBq,血管抑素12.5mg/kg),血管抑素(12.5mg/kg),131I(11.1MBq)和生理盐水各0.3mL,1次/周,治疗2次,观察14d内肿瘤体积的变化。结果:131I-血管抑素尾静脉注射后,48h内γ显像以全身分布为主,96h后肿瘤部位显像,并呈高度特异性浓集。131I-血管抑素,131I,血管抑素和生理盐水治疗两周后,各组小鼠Lewis肺癌移植瘤的平均体积分别为(1963±126),(5219±351),(3943±236),(7353±350)mm3,其抑瘤率分别为73.3%,29.0%,46.4%,与生理盐水组比较,差异有显著性意义(P=0.0003)。结论:131I-血管抑素可以高度特异性浓集于小鼠Lewis肺癌移植瘤部位,
OBJECTIVE: To observe the therapeutic effect of 131I-labeled angiostatin on Lewis lung carcinoma C57BL / 6 mice by radiosensitization and to evaluate the therapeutic effects of angiostatin, 131I-angiostatin and 131I alone on Lewis lung carcinoma in mice, To investigate the clinical application of 131I-angiostatin in the treatment of solid tumors. Methods: ①2001-02 / 05 in the Fourth Military Medical University Tangdu Hospital Nuclear Medicine Laboratory imaging experiments: chloramine-T method for 131I labeling, the labeled product 131I-angiostatin from the tail vein injection of Lewis lung cancer C57BL / 6 mice, 131I labeled albumin as a control, respectively, after 24,48,96,144 h ECT scan. ②2007-07-2003-07: In this laboratory, 28 C57BL / 6 mice bearing Lewis lung carcinoma (about 1 cm diameter subcutaneously transplanted right forelimb) were randomly divided into 4 groups, each of which was injected intraperitoneally with 131I-angiostatin Including 131I11.1MBq, angiostatin 12.5mg / kg), angiostatin (12.5mg / kg), 131I (11.1MBq) and normal saline 0.3mL, once per week for 2 times. The tumor volume The change. Results: After 131I-angiostatin was injected into the caudal vein, the distribution of γ imaging was mainly in the whole body within 48 hours. The tumor site was visualized after 96 hours and showed a highly specific concentration. After 131I-angiostatin, 131I, angiostatin and saline for two weeks, the average volume of Lewis lung carcinoma in each group was (1963 ± 126), (5219 ± 351), (3943 ± 236), (7353 ± 350) mm3, the inhibitory rates were 73.3%, 29.0% and 46.4%, respectively, which were significantly different from those in the saline group (P = 0.0003). Conclusion: 131I-angiostatin can be highly specific in mouse Lewis lung carcinoma xenografts,