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用４０～６０ｋｅＶ、剂量１×１０１１～５×１０１４ｉｏｎｓ／ｃｍ２的Ｎ＋离子注入红霉素产生菌后可产生可遗传的变异，在一定范围内红霉素产生菌的正向突变分布百分数与离子注入剂量正相关，离子注入后红霉素产生菌的菌落形态和孢子颜色发生变化，经筛选得到了高产突变菌株，摇瓶发酵表明高产突变菌株产量可提高２０％以上。与紫外线诱变相比，离子注入诱变具有突变范围广和突变程度高的特点。ＥＳＲ测试表明离子注入产生的自由基对生物效应基本上无影响，离子注入生物效应主要应由注入离子与生物分子的直接作用引起。对离子注入诱变的机理进行了探讨。
Erythromycin-producing bacteria were infested with 40-60 keV and 1 × 10 11-5 × 10 14 ions / cm 2 dose of N + ions. The percentage of positive mutation distribution of erythromycin-producing bacteria in a certain range and ion implantation Dose-dependent. The colony morphology and spore color of erythromycin-producing bacteria changed after ion implantation. High-yielding mutant strains were obtained by screening. The shake flask fermentation showed that the yield of mutant strains with high yield could be increased by more than 20%. Compared with UV mutagenesis, ion implantation mutagenesis has the characteristics of a wide range of mutations and high degree of mutation. ESR tests showed that the free radicals generated by ion implantation have almost no effect on the biological effects, and the biological effects of ion implantation should mainly be caused by the direct action of the implanted ions and the biomolecules. The mechanism of ion implantation mutagenesis was discussed.