美洲花椒(Zanthoxylum americanum)树生长于北美,曾从其皮和浆果中分离并鉴定出香豆素和生物碱类。本次研究了从茎和根皮中提取出的4种香豆素和2种木脂素的细胞毒活性。 材料和方法:将新鲜茎和根皮粉碎,用95％乙醇每日更换提取1周,提取物浓缩,浓缩物溶于水,分别用己烷、乙酸乙酯和正丁醇萃取。己烷部分上硅胶柱反 The Zanthoxylum americanum tree is grown in North America. It has isolated and identified coumarins and alkaloids from its skin and berries. The cytotoxic activities of 4 coumarins and 2 lignans extracted from the stem and root bark were studied. Materials and Methods: Fresh stalks and root bark were crushed and extracted daily with 95% ethanol for 1 week. The extracts were concentrated and the concentrate was dissolved in water and extracted with hexane, ethyl acetate and n-butanol, respectively. Hexane section on silica gel column