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体外实验已发现胆红素对人的血小板有抑制作用,有人还观察到动物输注胆红素后其出血倾向增加。本文作者拟通过对有黄疸新生儿的研究,以确定胆红素在人体内对血小板聚集的影响。观察对象分成三组:(1)试验组:生后3～20天之患高胆红素血症新生儿19例,临床无核黄疸证据,平均胆红素浓度为481微克分子/升(范围231～1147),间接胆红素浓度为406微克分子/升(范围211～839)。(2)对照组Ⅰ:正常成人20例,试验前1周内未用过包括阿斯匹林在内的任何药物。(3)对照组Ⅱ:无黄疸的、年龄相配之正常足月产新生儿13例。
In vitro experiments have found that bilirubin has an inhibitory effect on human platelets, it was also observed in animals after infusion of bilirubin bleeding tendency increased. The authors intend to pass jaundice in newborns to determine the effect of bilirubin on platelet aggregation in humans. Subjects were divided into three groups: (1) experimental group: 19 newborns with hyperbilirubinemia 3 to 20 days after birth, clinical evidence of non-nuclear jaundice, average bilirubin concentration of 481 micromoles / 231-1147) and an indirect bilirubin concentration of 406 μg / L (range 211-839). (2) Control group Ⅰ: 20 cases of normal adults, no drugs including aspirin were used within 1 week before the test. (3) control group Ⅱ: jaundice, age matched normal full-term newborn in 13 cases.