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目的观察右旋布洛芬治疗儿童发热的临床疗效。方法 420例发热患儿,以就诊先后顺序随机分为治疗组和对照组,每组210例。治疗组口服右旋布洛芬混悬液退热治疗;对照组口服布洛芬混悬液退热治疗,比较两组患儿的治疗效果及不良反应情况。结果治疗组患儿的治疗总有效率为89.52%,显著高于对照组的81.43%,差异具有统计学意义(P<0.05)。治疗组出现多汗5例,轻度恶心3例,轻度皮疹1例;对照组出现多汗76例,呕吐18例,轻度皮疹29例。治疗组的不良反应发生率4.29%低于对照组的58.57%,差异具有统计学意义(P<0.05)。两组停药后上述症状自行消失,均未见严重不良反应发生。结论右旋布洛芬在儿童退热治疗中具有用量小、效果好、不良反应少的特点,适合临床推广应用。
Objective To observe the clinical efficacy of dexibuprofen in the treatment of fever in children. Methods A total of 420 children with fever were randomly divided into treatment group and control group with 210 cases in each group. The treatment group was treated with oral dex-ibuprofen antipyretic. The control group was treated with oral ibuprofen suspension for fever relief. The therapeutic effects and adverse reactions of the two groups were compared. Results The total effective rate of the treatment group was 89.52%, which was significantly higher than that of the control group (81.43%), the difference was statistically significant (P <0.05). There were 5 cases of hyperhidrosis, 3 cases of mild nausea and 1 case of mild rash in the treatment group. There were 76 cases of hyperhidrosis, 18 cases of vomiting and 29 cases of mild rash in the control group. The incidence of adverse reactions in the treatment group was 4.29% lower than that in the control group (58.57%), the difference was statistically significant (P <0.05). The two groups after stopping the symptoms disappear on their own, no serious adverse reactions occurred. Conclusion dexibuprofen in children with antipyretic treatment with a small amount, good effect, fewer adverse reactions, suitable for clinical application.