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目的 通过血流动力学指标观察通心络胶囊对大鼠心肌缺血再灌注损伤的保护作用。方法 3 0大鼠随机分成假手术组、模型组和通心络通心络胶囊干预组。观察左冠脉前降支穿刺、结扎、再灌注前后大鼠的左室收缩内压 (LVSP)、左室内压最大变化速率 (±dp dtmax)等指标。结果 假手术组LVSP、±dp dtmax等指标与前降支结扎前均无显著性变化。模型组再灌注后的不同时段较冠脉前降支结扎前均有明显降低 ,且与假手术组比较均存在显著性差异 ,而通心络胶囊组虽与假手术组比较存在差异 ,但再灌注后不同时段与结扎前比较无均无明显差异、明显优于模型组。结论 通心络胶囊对大鼠受损心脏有明显的保护作用。
Objective To observe the protective effect of Tongxinluo capsule on myocardial ischemia-reperfusion injury in rats by using hemodynamic parameters. Methods 30 rats were randomly divided into sham operation group, model group and Tongxinluo Tongxinluo capsule intervention group. Left ventricular systolic pressure (LVSP) and maximum rate of left ventricular pressure (±dp dtmax) were measured before and after left anterior descending coronary artery puncture, ligation and reperfusion. Results There were no significant changes in LVSP, ±dp dtmax and other indicators in the sham group before the anterior descending coronary artery ligation. In the model group, the reperfusion time was significantly lower than that before the ligation of the anterior descending coronary artery. Compared with the sham operation group, there was a significant difference between the model group and the Tongxinluo capsule group. After the perfusion, there was no significant difference between the different time periods and before the ligation, which was obviously better than that of the model group. Conclusion Tongxinluo capsule has obvious protective effect on injured heart in rats.