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目的对比舍曲林与氟西汀治疗老年脑梗死后抑郁的疗效及安全性。方法将脑梗死后抑郁患者随机分为2组,分别口服舍曲林和氟西汀,疗程12周。采用汉密尔顿抑郁量表(HAMD)评定疗效,抗抑郁剂副反应量表(SERS)评价安全性,巴氏指数(BI)评定日常生活能力(ADL)。结果舍曲林和氟西汀治疗后HAMD评分均明显下降、BI显著升高,且随着治疗时间的延长变化更显著(P<0.001),但2组相比均无明显差异(P>0.05)。舍曲林组不良反应发生率明显低于氟西汀组(P<0.05)。结论舍曲林和氟西汀在改善老年脑梗死后抑郁和日常生活能力方面疗效相当,但舍曲林安全性更好。
Objective To compare the efficacy and safety of sertraline and fluoxetine in the treatment of depression after geriatric cerebral infarction. Methods Patients with depression after cerebral infarction were randomly divided into 2 groups: sertraline and fluoxetine, respectively, for 12 weeks. The Hamilton Depression Rating Scale (HAMD) was used to assess the efficacy, the antidepressant side effects scale (SERS) to evaluate the safety, and the Pap test (BI) to assess the daily living ability (ADL). Results After treatment with sertraline and fluoxetine, the HAMD scores were significantly decreased, BI significantly increased, and with the extension of treatment time more significant changes (P <0.001), but there was no significant difference between the two groups (P> 0.05 ). The incidence of adverse reactions in sertraline group was significantly lower than that in fluoxetine group (P <0.05). Conclusion Sertraline and fluoxetine have similar efficacy in improving depression and daily living ability in elderly patients with cerebral infarction, but sertraline is more safe.