论文部分内容阅读
目的评价消瘤汤联合化疗药物对中晚期消化系肿瘤患者的临床疗效,以及对免疫功能的影响。方法回顾性分析69例消瘤汤加化疗药物治疗的消化系肿瘤患者,并以52例同期收治的单纯使用化疗药物的患者为对照,比较两组的临床疗效、症状改善情况及卡氏(Karnofsky)评分;分析对免疫功能、外周血白细胞计数的影响。结果联合治疗组的总缓解率(53.6%)明显高于对照组(28.8%),恶心呕吐、乏力、纳差等症状的平均改善率(72.0%)亦明显高于对照组(49.2%);卡氏评分治疗组提高了33.3%,而对照组只提高13.5%;NK细胞活性和巨噬细胞功能联合治疗组也明显提高,两组比较有明显差异(P<0.05)。结论消瘤汤联合化疗药物对中晚期消化系肿瘤有显著疗效,明显优于单用化疗组。
Objective To evaluate the clinical efficacy of Xiaoliu Decoction combined with chemotherapy on patients with advanced digestive system tumors and their effects on immune function. Methods A retrospective analysis of 69 patients with digestive tumor treated with Xiaoyantang plus chemotherapeutic drugs was conducted. Twenty-two patients with chemotherapeutic drugs treated at the same period were compared. Clinical efficacy, symptom improvement and Karnofsky were compared between the two groups. Score; Analysis of immune function, peripheral blood leukocyte count. Results The overall response rate (53.6%) in the combined treatment group was significantly higher than that in the control group (28.8%). The mean improvement rate (72.0%) of nausea and vomiting, fatigue and anorexia was also significantly higher than that of the control group (49.2%). The Karnofsky score increased by 33.3% in the treatment group and only 13.5% in the control group. The combination of NK cell activity and macrophage function was also significantly improved in both groups (P <0.05). Conclusion Xiaoliu Decoction combined with chemotherapy drugs have a significant effect on the digestive system tumors in the advanced stage, which is obviously better than the chemotherapy alone group.