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目的:利用唾液检测的优势,建立一种快速、无创、准确筛查“冰毒”依赖者的新方法。方法:应用表面增强拉曼技术对“冰毒”依赖者和未吸毒者的唾液进行光谱检测,获得其拉曼光谱。通过光谱分析找到区分两组人群的有效依据。并对40例样本进行唾液筛查的验证实验,以进一步证明此筛查方法的可行性。结果:“冰毒”依赖者唾液的拉曼光谱在1000、1029 cm-1处分别出现强谱和中强谱,表明其中存在“冰毒”及其活性衍生物。验证实验能准确区分两组人群。结论:基于表面增强拉曼技术的唾液检测可实现对“冰毒”依赖者的筛查,此方法具有快速灵敏、操作方便、成本低及无污染等优势。
OBJECTIVE: To establish a rapid, noninvasive and accurate method for the screening of “methamphetamine” dependent patients by using the advantages of saliva detection. Methods: The saliva of the “ice poison” dependent and non-drug users were detected by surface enhanced Raman spectroscopy, and their Raman spectra were obtained. Through spectral analysis to find effective basis to distinguish between two groups of people. And 40 cases of saliva screening validation test to further prove the feasibility of this screening method. Results: The strong and middle strong spectra of the saliva of the “ice poisoned” dependent persons appeared at 1000 and 1029 cm-1, respectively, indicating that there exists “ice crystal” and its active derivatives. Validation experiments can accurately distinguish between two groups of people. CONCLUSIONS: Saliva testing based on surface-enhanced Raman spectroscopy can screen for “ice poisoning” dependent patients. This method is rapid, sensitive, easy to operate, low cost and non-polluting.