论文部分内容阅读
对急性心肌梗塞（ＡＭＩ）患者１１９例，行尿激酶天普洛欣（ＵＫＴＰ）静脉溶栓治疗。半小时输注１５０万单位（５５例，Ａ组）或２００万单位（６４例，Ｂ组）。结果：①临床判断梗塞相关血管总再通率为６７．２％，病死率０．７％（其中心脏因素病死率５．９％）。②Ａ与Ｂ组血管再通率（７２．７％ＶＳ６２．５％），病死率（７．３％ＶＳ６．３％）及并发症均天显著性差异（ｐ＞０．０５）。③溶栓再通患者病死率（２．５％，２／８０例）明显低于未溶通者（１５．４％，６／３９例）且前者ＫｉｌｌｉｐⅢ级以上泵衰竭（２／８０例）也明显少于未溶通者（１５／３９例）。上述ｐ值均＜０．０１。④初步探讨分两次每次１００万单位，５至１０分钟内注射间隔５０分钟静脉推注ＵＫＴＰ，５例中４例血管再通。⑤ＡＭＩ溶栓后９０分钟冠脉造影１５例，１２例血管开通（８０．０％）均与临床判断相符，ＵＫＴＰ对溶栓安全有效。
119 patients with acute myocardial infarction (AMI) were treated with intravenous thrombolysis of UKTP. Half a hour infusion of 1.5 million units (55 cases, A group) or 2 million units (64 cases, B group). Results: ① The total recanalization rate of infarction-related blood vessels was 67.2% and the case fatality rate was 0.7% (the mortality rate of cardiac factors was 5.9%). ② The recanalization rates (72.7% VS62.5%) and mortality (7.3% vs 6.3%) in group A and B were significantly higher than those in group B (p> 0.05). (3) The mortality rate of patients with thrombolysis recanalization (2.5%, 2/80 cases) was significantly lower than those without recanalization (15.4%, 6/39 cases) Also significantly less than those who did not pass (15/39 cases). The above p values were <0.01. ④ preliminary study of two million times each 100 million units, 5 to 10 minutes intravenous injection of UKTP 50 minutes intervals, 5 cases of 4 cases of recanalization. ⑤AMI 15 minutes after coronary angiography thrombolysis, 12 cases of vascular opening (80.0%) were consistent with clinical judgment, UKTP safe and effective thrombolysis.