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目的评价葛根素注射液(PI)联合低分子肝素(LMWH)治疗不稳定型心绞痛(UAP)的疗效和安全性。方法计算机检索中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP-维普)、万方-数字化期刊全文库,纳入在常规治疗上加用PI和LMWH对比单纯常规治疗的随机对照试验(RCT),对纳入研究进行质量评价和Meta分析。结果共纳入21个RCT,均为C级文献。Meta分析结果显示,在临床症状疗效显效率、心电图疗效显效率和有效率指标方面,两组差异有统计学意义:RR(95%CI)分别为:1.63(1.48,1.79)、1.57(1.34,1.83)及1.28(1.10,1.49)。结论基于上述证据,在常规治疗UAP上加用PI和LMWH疗效优于常规治疗。
Objective To evaluate the efficacy and safety of puerarin (PI) combined with low molecular weight heparin (LMWH) in the treatment of unstable angina pectoris (UAP). Methods We searched the Chinese Biomedical Literature Database (CBM), Chinese Journal Full-text Database (CNKI), Chinese Science and Technology Periodical Full-text Database (VIP-VIP) and Wanfang- Randomized controlled trials (RCTs) with routine treatment were included in the study to assess quality and meta-analysis. Results A total of 21 RCTs were included, all of which were C-level documents. The results of Meta analysis showed that there was significant difference between the two groups in terms of effective rate of clinical symptom curative effect, effective curative effect and effective rate of electrocardiogram curative effect: RR (95% CI) were 1.63 (1.48,1.79), 1.57 (1.34, 1.83) and 1.28 (1.10, 1.49). Conclusions Based on the above evidence, the addition of PI and LMWH to conventional treatment of UAP is superior to conventional treatment.