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目的：分析侵袭性血管粘液瘤的临床和病理学特点。方法：对１９８８年３月～１９９８年６月我院收治的４例侵袭性血管粘液瘤患者的临床资料进行回顾性分析，并对其病理切片行免疫组化染色。结果：４例均为女性，年龄３９～５０岁；３例发生在外阴，１例在盆腔底部。肿瘤最大径４～１５ｃｍ。免疫组化染色肿瘤细胞阳性反应分别为ｖｉｍｅｎｔｉｎ（４／４）、ｄｅｓｍｉｎ（４／４）、ａｃｔｉｎ（１／４）、ＳＭＡ（１／４）、ＣＤ３４（３／４），Ｓ１００蛋白为阴性；雌激素受体、孕激素受体全部呈强阳性表达。随访４例均无复发和转移。结论：侵袭性血管粘液瘤是一种少见的特征性的间叶性肿瘤，主要累及成年女性的会阴和盆腔，肿瘤呈浸润性生长，但不发生转移。肿瘤具有鲜明的病理组织学特点，免疫组化显示肿瘤细胞可能为纤维母细胞／肌纤维母细胞来源，在其生长过程中激素可能起一定的作用。
Objective: To analyze the clinical and pathological features of invasive vascular myxoma. Methods: March 1988 - June 1998, clinical data of four cases of invasive angiomyxoma patients in our hospital were retrospectively analyzed, and its pathological immunohistochemical staining. Results: All 4 cases were female, aged 39-50 years old; 3 cases occurred in the vulva and 1 case was in the bottom of the pelvis. The maximum diameter of the tumor is 4-15cm. Immunohistochemical staining of tumor cells were positive to vimentin (4/4), desmin (4/4), actin (1/4), SMA (1/4), CD34 (3/4), S100 protein Negative; Estrogen and progesterone receptors all showed strong positive expression. Follow-up of 4 patients had no recurrence or metastasis. Conclusion: aggressive angiomyxoma is a characteristic rare mesenchymal tumors, mainly involving adult female pelvis and perineum, the tumors were invasive growth, but do not metastasize. Tumor has a distinct histopathological features, display immunohistochemical tumor cells may be fibroblasts / blasts muscle fiber sources, hormones may play a role in their growth process.